Severe aortic stenosis and ischemic coronary artery disease are frequently associated in elderly patients, adding complexity to interventional management. Diastolic dysfunction, a marker of myocardial impairment and elevated filling pressures, may influence prognosis after transcatheter aortic valve implantation (TAVI), particularly in the presence of concomitant coronary pathology. The aim of the study was to analyze the interaction between severe aortic valve stenosis, left ventricular diastolic dysfunction, and coronary ischemia in elderly patients with complex cardiovascular disease.
The common carotid artery is the main source of blood supply to the head and neck regions. Its branching patterns are of great interest in terms of both anatomical and clinical significance. Variability of the common carotid artery can influence the planning of vascular, endovascular and oncological interventions in the head and neck regions, to avoid vessel injuries as well as intra-operative and postoperative complications.
The data reported in the specialty literature on the embryogenesis of the facial nerve mainly refer to the initial stages of its development. Nevertheless, the intrauterine development of the facial nerve is a complex and insightful process, characterized by a range of peculiarities. The goal of our study was to highlight the specific developmental features of the facial nerve for a better understanding of its morphology in adults
Acute type A aortic dissection represents a life-threatening cardiovascular emergency with catastrophic natural history and extremely high mortality in the absence of prompt surgical intervention. Over the last decades, surgical management has evolved from supracoronary replacement and composite root replacement (Bentall procedure) towards valve-sparing strategies, among which the Tirone David reimplantation procedure has gained increasing acceptance.
Scleroderma Renal Crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc), traditionally associated with anti-RNA polymerase III antibodies, corticosteroid use, and diffuse skin involvement. However, the role of COVID-19 as a potential trigger for SRC remains poorly understood. This study explores the occurrence of COVID-19-associated SRC, focusing on its clinical presentation, underlying risk factors, and outcomes
Chronic kidney disease (CKD) is a major and growing global public health problem, contributing to significant morbidity, mortality, and financial strain on healthcare systems. Despite available preventive measures, CKD often remains underdiagnosed and insufficiently addressed by health policies worldwide.
Neuropsychiatric lupus erythematosus is still a disease with a very challenging diagnostic process, lacking high specificity and sensitivity assays. Autoantibodies can change this perspective, and because of their pathogenetic involvement, can become a very powerful tool for early detection and disease activity tracking. However, their biomarker potential still needs further evaluation. In this study, we focused on the pathogenetic mechanisms of neuropsychiatric lupus erythematosus and the involvement of brain-specific and systemic autoantibodies in the development of neuropsychiatric manifestations.
Even if boron is not yet recognized as an essential element for the human body, its insufficient intake is considered harmful, especially for the osteoarticular system. A daily intake of at least 3 mg of boron can fortify bone mass and prevent the onset of osteoarthritis, rheumatoid arthritis, and osteoporosis. This research aims to assess the morbidity caused by rheumatoid arthritis and inflammatory polyarthropathies in the population from regions with different boron concentrations in deep drinking water of the Republic of Moldova.