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From prolonged premature rupture of membranes to bronchopulmonary dysplasia: the role of chorioamnionitis in the respiratory outcomes of preterm infants
Liuba Dascaliuc1*, Larisa Crivceanscaia1, Ludmila Oclanschi1, Ninel Revenco1, Angela Cracea1, Zinaida Sârbu2
https://doi.org/10.52645/MJHS.2026.1.04
Prolonged premature rupture of membranes predisposes to intrauterine infection and chorioamnionitis, both of which have significant implications for neonatal outcomes. While chorioamnionitis has been linked to accelerated surfactant production and reduced respiratory distress syndrome, it is also associated with long-term pulmonary injury, including bronchopulmonary dysplasia and pulmonary hypertension. The objective of the study is to investigate the association between prolonged premature rupture of membranes, chorioamnionitis, and respiratory outcomes among preterm infants ≤34 weeks of gestation.