Currently, extensive research has shown that almost all published prediction models are poorly studied and have significant limitations, leading to their predictive performance often being overestimated. Additionally, there is still no universally accepted scoring system, primarily due to the need for adaptation to heterogeneous patient samples (including patient numbers, clinical profiles, and risk factors) and/or ongoing differences in the organization of healthcare systems across various countries.
Gastric intestinal metaplasia and gastric epithelial dysplasia – precursor lesions of gastric cancer
Despite worldwide decreasing trends in the incidence of gastric cancer, the disease remains a significant global health burden, one of the leading causes of cancer death worldwide, and its prevention is a priority for the health system. Intestinal-type gastric carcinoma originates in dysplastic epithelium, which, in turn, develops in the environment of chronic atrophic gastritis and gastric intestinal metaplasia.
Carotenoids and chlorophylls are plant pigments that play a vital role in plant life, participating in the process of photosynthesis and in the synthesis of growth regulators, stress signalers and fungicide attack agents. Research from the last decades has shown that, widely used as nutrients, chlorophyll and carotenoid pigments have beneficial effects on the human body. They exert antioxidant, energizing, detoxifying, anti-inflammatory properties, and can be applied in the prevention and treatment of 21st century diseases (cancer, cardiovascular diseases, low immunity), which are related to numerous causal factors (excessive chemicalization of the food industry, progressive climate change and environmental pollution), which reflects on the quality of human health.
In the context of increasing global consumption of bottled water, assessing its chemical composition and impact on public health becomes essential. Although perceived as a safe alternative, bottled water exhibits variability in its chemical composition, and advanced filtration methods can remove essential minerals. Consumers opt for bottled water due to its taste and convenience, yet awareness of associated risks remains limited. This study proposes the development and validation of a questionnaire to evaluate public perceptions of bottled water
The irrational use of antibiotics is one of the main factors contributing to the accelerated development of antimicrobial resistance worldwide. Despite the regulations established to control the procurement of antimicrobial drugs, the rate of self-prescribing and self-treatment with antimicrobials remains very high in most countries. To plan further measures to combat this resistance, a thorough understanding of the current reasons behind this behavior is required. The aim of the study is to explore the general public's knowledge, attitudes, and behavior regarding antibiotic consumption.
Globally, colorectal cancer (CRC) has become one of the top three causes of death from neoplasms. CRC represents a heterogeneous group of tumors, manifested both by clinical signs and the pathogenesis of its development. Most colorectal carcinomas develop from preexisting adenomas. The aim of this article is to assess the histopathological aspects and variants of primary colon neoformations in correlation with their location and morphological characteristics
The superficial circumflex iliac artery (SCIA) is a branch that originates either from the external iliac artery (EIA), or common femoral artery (CFA). Its anatomic variability is particularly relevant in plastic surgery, general surgery, and traumatology/orthopedics
Psoriatic arthritis (PsA) is a complex autoimmune disease with genetic and immunological components influencing its pathogenesis. HLA antigens are critical in determining genetic predisposition and clinical variability. This study aims to explore HLA antigen diversity in PsA patients and its relationship to clinical variants.
Axial spondylitis is a chronic inflammatory disease primarily affecting the axial skeleton but can also involve peripheral joints. Axial spondylitis is often associated with extra-articular manifestations, such as inflammatory bowel diseases, emphasizing the need for rigorous monitoring and personalized therapeutic approaches. The interactions between axial spondylitis and inflammatory bowel diseases fall under the concept of “immune-mediated inflammatory diseases”, sharing common pathogenetic mechanisms. This study analyzes the prevalence and characteristics of inflammatory bowel diseases in patients with axial spondylitis
Hemophilia is a genetic disorder characterized by impaired blood coagulation, leading to increased bleeding risk. The severity of hemophilia varies significantly among individuals, influenced by genetic factors, family inheritance patterns, and the occurrence of complications such as hemarthrosis. Understanding these interrelationships is crucial for developing tailored management strategies for affected children. The purpose of this article is to explore the correlations between clinical severity and various factors, including modes of inheritance, hemarthrosis incidence, types of genetic mutations, and inhibitor presence in pediatric patients with hemophilia. By elucidating these relationships, the study aims to contribute to improved diagnostic and therapeutic approaches in this population.